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JAK3STAT56 Pathway Alterations Are Associated with Immune Deviation in CD8+ T Cells in Renal Cell Carcinoma Patients
Joint Authors
Cincione, Raffaele I.
Cavalcanti, Elisabetta
Ditonno, Pasquale
Battaglia, Michele
Gigante, Margherita
Mancini, Vito
Selvaggi, Francesco P.
Capobianco, Carmela
Storkus, Walter J.
Gesualdo, Loreto
Ranieri, Elena
Herr, Wolfgang
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
To investigate the molecular mechanisms underlying altered T cell response in renal cell carcinoma (RCC) patients, we compared autologous and allogeneic CD8+ T cell responses against RCC line from RCC patients and their HLA-matched donors, using mixed lymphocyte/tumor cell cultures (MLTCs).
In addition, we analyzed the expression of molecules associated with cell cycle regulation.
Autologous MLTC responder CD8+ T cells showed cytotoxic activity against RCC cell lines; however the analysis of the distribution of CD8+ T-cell subsets revealed that allogenic counterparts mediate superior antitumor efficacy.
In RCC patients, a decreased proliferative response to tumor, associated with defects in JAK3/STAT5/6 expression that led to increased p27KIP1 expression and alterations in the cell cycle, was observed.
These data define a molecular pathway involved in cell cycle regulation that is associated with the dysfunction of tumor-specific CD8+ effector cells.
If validated, this may define a therapeutic target in the setting of patients with RCC.
American Psychological Association (APA)
Cavalcanti, Elisabetta& Gigante, Margherita& Mancini, Vito& Battaglia, Michele& Ditonno, Pasquale& Capobianco, Carmela…[et al.]. 2010. JAK3STAT56 Pathway Alterations Are Associated with Immune Deviation in CD8+ T Cells in Renal Cell Carcinoma Patients. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-509518
Modern Language Association (MLA)
Cavalcanti, Elisabetta…[et al.]. JAK3STAT56 Pathway Alterations Are Associated with Immune Deviation in CD8+ T Cells in Renal Cell Carcinoma Patients. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-509518
American Medical Association (AMA)
Cavalcanti, Elisabetta& Gigante, Margherita& Mancini, Vito& Battaglia, Michele& Ditonno, Pasquale& Capobianco, Carmela…[et al.]. JAK3STAT56 Pathway Alterations Are Associated with Immune Deviation in CD8+ T Cells in Renal Cell Carcinoma Patients. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-509518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509518