Combination Therapy of Interferon Beta-1b and Tacrolimus : A Pilot Safety Study
Joint Authors
Gaboury, I.
Grand'Maison, F.
Jacques, F.
Christie, S.
Source
Multiple Sclerosis International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Tacrolimus is a calcineurin inhibitor which works to induce immune suppression by preventing cytokine transcription and lymphocyte activation.
Combining the immunomodulator interferon beta-1b (Betaseron) with the immunosuppressant tacrolimus (Prograf) may have the potential of additive therapeutic benefit through the complementary mechanisms of action of these two therapeutics.
In this randomized, open-label, multicenter, two-arm pilot study, the authors examined the safety and tolerability of the combination of interferon beta-1b and tacrolimus in relapsing remitting (RRMS) and secondary progressive (SPMS) multiple sclerosis patients who have failed one or more immunomodulatory therapies.
Patients (n=25) received a combination of interferon beta-1b subcutaneously every other day and oral tacrolimus (low blood level tacrolimus, 1–5 ng/mL, or high blood level tacrolimus, 5–10 ng/mL) for a period of 38 weeks.
The combination therapy of interferon beta-1b and tacrolimus over the 10-month period of the study was shown to be safe and relatively well tolerated.
There were no unexpected adverse events occurring as the result of the combination therapy.
Further study of this combination therapy in patients with multiple sclerosis unresponsive to conventional therapy is warranted.
American Psychological Association (APA)
Jacques, F.& Gaboury, I.& Christie, S.& Grand'Maison, F.. 2012. Combination Therapy of Interferon Beta-1b and Tacrolimus : A Pilot Safety Study. Multiple Sclerosis International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-509529
Modern Language Association (MLA)
Jacques, F.…[et al.]. Combination Therapy of Interferon Beta-1b and Tacrolimus : A Pilot Safety Study. Multiple Sclerosis International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-509529
American Medical Association (AMA)
Jacques, F.& Gaboury, I.& Christie, S.& Grand'Maison, F.. Combination Therapy of Interferon Beta-1b and Tacrolimus : A Pilot Safety Study. Multiple Sclerosis International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-509529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509529