Failure of Supervised Chloroquine and Primaquine Regimen for the Treatment of Plasmodium vivax in the Peruvian Amazon
Joint Authors
Graf, Paul C. F.
Lucas, Carmen
Montalvan, Carmen
Bacon, David J.
Fryauff, David J.
Salas, Carola
Durand, Salomon
Green, Michael D.
Santolalla, Meddly L.
Alvarez Antonio, Carlos
Galves Montoya, Mariella
Source
Malaria Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The widespread use of primaquine (PQ) and chloroquine (CQ), together, may be responsible for the relatively few, isolated cases of chloroquine-resistant P.
vivax (CQRPV) that have been reported from South America.
We report here a case of P.
vivax from the Amazon Basin of Peru that recurred against normally therapeutic blood levels of CQ.
Four out of 540 patients treated with combination CQ and PQ had a symptomatic recurrence of P.
vivax parasitemia within 35 days of treatment initiation, possibly indicating CQ failure.
Whole blood total CQ level for one of these four subjects was 95 ng/ml on the day of recurrence.
Based on published criteria that delineate CQRPV as a P.
vivax parasitemia, either recrudescence or relapse, that appears against CQ blood levels >100 ng/mL, we document the occurrence of a P.
vivax strain in Peru that had unusually high tolerance to the synergistic combination therapy of CQ + PQ that normally works quite well.
American Psychological Association (APA)
Graf, Paul C. F.& Durand, Salomon& Alvarez Antonio, Carlos& Montalvan, Carmen& Galves Montoya, Mariella& Green, Michael D.…[et al.]. 2012. Failure of Supervised Chloroquine and Primaquine Regimen for the Treatment of Plasmodium vivax in the Peruvian Amazon. Malaria Research and Treatment،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-509539
Modern Language Association (MLA)
Graf, Paul C. F.…[et al.]. Failure of Supervised Chloroquine and Primaquine Regimen for the Treatment of Plasmodium vivax in the Peruvian Amazon. Malaria Research and Treatment No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-509539
American Medical Association (AMA)
Graf, Paul C. F.& Durand, Salomon& Alvarez Antonio, Carlos& Montalvan, Carmen& Galves Montoya, Mariella& Green, Michael D.…[et al.]. Failure of Supervised Chloroquine and Primaquine Regimen for the Treatment of Plasmodium vivax in the Peruvian Amazon. Malaria Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-509539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509539