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Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans
Joint Authors
Lipton, Jonathan A.
de Crom, Rini
Segers, Dolf
Tempel, Dennie
Cheng, Caroline
Leenen, Pieter J. M.
Krams, Rob
Moll, Frans L.
Pasterkamp, Gerard
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The chemokine CXCL10 is specifically upregulated during experimental development of plaque with an unstable phenotype.
In this study we evaluated the functional consequences of these findings in mice and humans.
Methods and Results.
In ApoE-/- mice, we induced unstable plaque with using a flow-altering device around the carotid artery.
From week 1 to 4, mice were injected with a neutralizing CXCL10 antibody.
After 9 weeks, CXCL10 inhibition resulted in a more stable plaque phenotype: collagen increased by 58% (P=0.002), smooth muscle cell content increased 2-fold (P=0.03), while macrophage MHC class II expression decreased by 50% (P=0.005).
Also, the size of necrotic cores decreased by 41% (P=0.01).
In 106 human carotid endarterectomy specimens we found that increasing concentrations of CXCL10 strongly associate with an increase in atheromatous plaque phenotype (ANOVA, P=0.003), with high macrophage, low smooth muscle cell, and low collagen content.
Conclusions.
In the present study we showed that CXCL10 is associated with the development of vulnerable plaque in human and mice.
We conclude that CXCL10 might provide a new lead towards plaque-stabilizing therapy.
American Psychological Association (APA)
Segers, Dolf& Lipton, Jonathan A.& Leenen, Pieter J. M.& Cheng, Caroline& Tempel, Dennie& Pasterkamp, Gerard…[et al.]. 2011. Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-509545
Modern Language Association (MLA)
Segers, Dolf…[et al.]. Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans. International Journal of Inflammation No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-509545
American Medical Association (AMA)
Segers, Dolf& Lipton, Jonathan A.& Leenen, Pieter J. M.& Cheng, Caroline& Tempel, Dennie& Pasterkamp, Gerard…[et al.]. Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-509545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509545