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Articular Cartilage Gene Expression after Coxofemoral Joint Luxation in the Dog
Joint Authors
Chomdej, Siriwadee
Nganvongpanit, Korakot
Pradit, Waranee
Source
Veterinary Medicine International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study examined the relationship between days of hip luxation and the expression of various mRNA.
Twenty-six articular cartilages were used in the experiment: 3 samples were from normal dogs and 23 samples were collected from the femoral heads of hips that had been luxated for different lengths of time.
Ten mRNA, including nonapoptotic genes (AGG, COL2A1, MMP-3, HAS-1, HAS-2, and TIMP-1) and apoptotic genes (BAX, BCL-2, CAS-3, and CAS-9), were studied for their expression using real-time PCR.
We found very high correlation between expression level and luxation days (r2>0.9) in COL2A1, MMP-3, HAS-1, HAS-2, TIMP-1, BAX, and CAS-9, while the others (AGG, BCL-2, and CAS-3) also showed high correlation (r2=7–9).
And we found a significant difference (P<0.05) in the expression of transcripts depending on the number of luxation days.
In conclusion, a delay in joint reduction may increase the chances of development of osteoarthritis.
American Psychological Association (APA)
Nganvongpanit, Korakot& Pradit, Waranee& Chomdej, Siriwadee. 2013. Articular Cartilage Gene Expression after Coxofemoral Joint Luxation in the Dog. Veterinary Medicine International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-509564
Modern Language Association (MLA)
Nganvongpanit, Korakot…[et al.]. Articular Cartilage Gene Expression after Coxofemoral Joint Luxation in the Dog. Veterinary Medicine International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-509564
American Medical Association (AMA)
Nganvongpanit, Korakot& Pradit, Waranee& Chomdej, Siriwadee. Articular Cartilage Gene Expression after Coxofemoral Joint Luxation in the Dog. Veterinary Medicine International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-509564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509564