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Anti-Proliferative Effect of an Aqueous Extract of Prunella vulgaris in Vascular Smooth Muscle Cells
Joint Authors
Lee, Yong Pyo
Kang, Dae Gill
Lee, Yun Jung
Choi, Kyung Min
Lee, So Min
Yoon, Jung Joo
Lee, Ho Sub
Cha, Jeong Dan
Hwang, Sun Mi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The abnormal proliferation of vascular smooth muscle cells (VSMCs) in arterial walls is an important pathogenic factor of vascular disorders such as diabetic atherosclerosis.
We have reported the anti-inflammatory effect of an aqueous extract from Prunella vulgaris (APV) in vascular endothelial cell.
In the present study, APV exhibited inhibitory effects on high glucose-stimulated VSMC proliferation, migration, and invasion activities, inducing G1 cell cycle arrest with downregulation of cyclins and CDKs and upregulation of the CKIs, p21waf1/cip1 and p27kip1.
Furthermore, APV dose dependently suppressed the high glucose-induced matrix metalloproteinase activity.
High glucose-induced phosphorylation of ERK, p38 MAPK, was decreased by the pretreatment of APV.
NF-κB activation by high glucose was attenuated by APV, as an antioxidant.
APV attenuated the high glucose-induced decrease of nuclear factor E2-related factor-2 (Nrf2) translocation and heme oxygenase-1 (HO-1) expression.
Intracellular cGMP level was also increased by APV treatment.
These results demonstrate that APV may inhibit VSMC proliferation via downregulating ROS/NF-κB /ERK/p38 MAPK pathways.
In addition, APV has a beneficial effect by the interaction of Nrf2-mediated NO/cGMP with HO-1, suggesting that Prunella vulgaris may be useful in preventing diabetic atherosclerosis.
American Psychological Association (APA)
Hwang, Sun Mi& Lee, Yun Jung& Lee, Yong Pyo& Yoon, Jung Joo& Lee, So Min& Cha, Jeong Dan…[et al.]. 2013. Anti-Proliferative Effect of an Aqueous Extract of Prunella vulgaris in Vascular Smooth Muscle Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-509576
Modern Language Association (MLA)
Hwang, Sun Mi…[et al.]. Anti-Proliferative Effect of an Aqueous Extract of Prunella vulgaris in Vascular Smooth Muscle Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-509576
American Medical Association (AMA)
Hwang, Sun Mi& Lee, Yun Jung& Lee, Yong Pyo& Yoon, Jung Joo& Lee, So Min& Cha, Jeong Dan…[et al.]. Anti-Proliferative Effect of an Aqueous Extract of Prunella vulgaris in Vascular Smooth Muscle Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-509576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509576