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Genetic Dissection of the AZF Regions of the Human Y Chromosome : Thriller or Filler for Male (In)fertility?
Joint Authors
Gonçalves, João
Navarro-Costa, Paulo
Plancha, Carlos E.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-30
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The azoospermia factor (AZF) regions consist of three genetic domains in the long arm of the human Y chromosome referred to as AZFa, AZFb and AZFc.
These are of importance for male fertility since they are home to genes required for spermatogenesis.
In this paper a comprehensive analysis of AZF structure and gene content will be undertaken.
Particular care will be given to the molecular mechanisms underlying the spermatogenic impairment phenotypes associated to AZF deletions.
Analysis of the 14 different AZF genes or gene families argues for the existence of functional asymmetries between the determinants; while some are prominent players in spermatogenesis, others seem to modulate more subtly the program.
In this regard, evidence supporting the notion that DDX3Y, KDM5D, RBMY1A1, DAZ, and CDY represent key AZF spermatogenic determinants will be discussed.
American Psychological Association (APA)
Navarro-Costa, Paulo& Plancha, Carlos E.& Gonçalves, João. 2010. Genetic Dissection of the AZF Regions of the Human Y Chromosome : Thriller or Filler for Male (In)fertility?. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-509591
Modern Language Association (MLA)
Navarro-Costa, Paulo…[et al.]. Genetic Dissection of the AZF Regions of the Human Y Chromosome : Thriller or Filler for Male (In)fertility?. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-18.
https://search.emarefa.net/detail/BIM-509591
American Medical Association (AMA)
Navarro-Costa, Paulo& Plancha, Carlos E.& Gonçalves, João. Genetic Dissection of the AZF Regions of the Human Y Chromosome : Thriller or Filler for Male (In)fertility?. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-509591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509591