Chronic Proliferative Dermatitis in Mice : NFκB Activation Autoinflammatory Disease
Author
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Autoinflammatory diseases are a heterogeneous group of congenital diseases characterized by the presence of recurrent inflammation, in the absence of infectious agents, detectable autoantibodies or antigen-specific autoreactive T-cells.
SHARPIN deficient mice presents multiorgan chronic inflammation without known autoantibodies or autoreactive T-cells, designated Sharpincpdm.
Histological studies demonstrated epidermal hyperproliferation, Th-2 inflammation, and keratinocyte apoptosis in this mutant.
The mutant mice have decreased behavioral mobility, slower growth, and loss of body weight.
Epidermal thickness and mitotic epidermal cells increase along with disease development.
K5/K14 expression is distributed through all layers of epidermis, along with K6 expression in interfollicular epidermis, suggesting epidermal hyperproliferation.
K1/K10 is only detectable in outer layers of spinosum epidermis, reflecting accelerated keratinocyte migration.
Alpha smooth muscle actin is overexpressed in skin blood vessels, which may release the elevated white blood cells to dermis.
CD3+CD45+ cells and granulocytes, especially eosinophils and mast cells, aggregate in the mutant skin.
TUNEL assay, together with Annexin-V/propidium iodide FACS analysis, confirmed the increase of apoptotic keratinocytes in skin.
These data validate and provide new lines of evidence of the proliferation-inflammation-apoptosis triad in Sharpincpdm mice, an NFκB activation autoinflammatory disease.
American Psychological Association (APA)
Liang, Yanhua. 2011. Chronic Proliferative Dermatitis in Mice : NFκB Activation Autoinflammatory Disease. Pathology Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-509600
Modern Language Association (MLA)
Liang, Yanhua. Chronic Proliferative Dermatitis in Mice : NFκB Activation Autoinflammatory Disease. Pathology Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-509600
American Medical Association (AMA)
Liang, Yanhua. Chronic Proliferative Dermatitis in Mice : NFκB Activation Autoinflammatory Disease. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-509600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509600