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Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands
Joint Authors
Ribeiro, João P.
Morais, Tânia S.
Lorenzo, Julia
Florindo, Pedro
Robalo, M. Paula
Aviles, Francesc X.
Garcia, M. Helena
Moreno, Virtudes
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Four cationic ruthenium(II) complexes with the formula [Ru(η5-C5H5)(PPh3)2]+, with L=5-phenyl-1H-tetrazole (TzH) 1, imidazole (ImH) 2, benzo[1,2-b;4,3-b′] dithio-phen-2-carbonitrile (Bzt) 3, and [5-(2-thiophen-2-yl)-vinyl]-thiophene-2-carbonitrile] (Tvt) 4 were prepared and characterized in view to evaluate their potentialities as antitumor agents.
Studies by Circular Dichroism indicated changes in the secondary structure of ct-DNA.
Changes in the tertiary structure of pBR322 plasmid DNA were also observed in gel electrophoresis experiment and the images obtained by atomic force microscopy (AFM) suggest strong interaction with pBR322 plasmid DNA; the observed decreasing of the viscosity with time indicates that the complexes do not intercalate between DNA base pairs.
Compounds 1, 2, and 3 showed much higher cytotoxicity than the cisplatin against human leukaemia cancer cells (HL-60 cells).
American Psychological Association (APA)
Moreno, Virtudes& Lorenzo, Julia& Aviles, Francesc X.& Garcia, M. Helena& Ribeiro, João P.& Morais, Tânia S.…[et al.]. 2010. Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands. Bioinorganic Chemistry and Applications،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-509602
Modern Language Association (MLA)
Moreno, Virtudes…[et al.]. Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands. Bioinorganic Chemistry and Applications No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-509602
American Medical Association (AMA)
Moreno, Virtudes& Lorenzo, Julia& Aviles, Francesc X.& Garcia, M. Helena& Ribeiro, João P.& Morais, Tânia S.…[et al.]. Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands. Bioinorganic Chemistry and Applications. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-509602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509602