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Novel Strategy with Gemcitabine for Advanced Pancreatic Cancer
Joint Authors
Komori, Shuji
Osada, Shinji
Yoshida, Kazuhiro
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
5-fluorouracil (5-FU) is widely used in chemotherapy for gastric and colorectal cancer, but gemcitabine (GEM), and not 5-FU, is approved as a standard drug for use in pancreatic cancer.
Interindividual variation in the enzyme activity of the GEM metabolic pathway can affect the extent of GEM metabolism and the efficacy of GEM chemotherapy.
Human equilibrative nucleoside transporter 1 (hENT1) is recognized as a major transporter of GEM into cells.
In addition, a factor that activates hENT1 is the inhibition of thymidylate synthase (TS), one of the 5-FU metabolic enzymes; TS inhibition mediates depleting intracellular nucleotide pools, resulting in the activation of the salvage pathway mediated through hENT1.
In this paper, the role of 5-FU in GEM-based chemotherapy for pancreatic cancer is discussed with special emphasis on enzymes involved in the 5-FU and GEM metabolic pathways and in the correlation between GEM responsiveness and the expression of 5-FU and GEM metabolic enzymes.
American Psychological Association (APA)
Komori, Shuji& Osada, Shinji& Yoshida, Kazuhiro. 2011. Novel Strategy with Gemcitabine for Advanced Pancreatic Cancer. ISRN Oncology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-509611
Modern Language Association (MLA)
Komori, Shuji…[et al.]. Novel Strategy with Gemcitabine for Advanced Pancreatic Cancer. ISRN Oncology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-509611
American Medical Association (AMA)
Komori, Shuji& Osada, Shinji& Yoshida, Kazuhiro. Novel Strategy with Gemcitabine for Advanced Pancreatic Cancer. ISRN Oncology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-509611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509611