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Renal Overexpression of Atrial Natriuretic Peptide and Hypoxia Inducible Factor-1α as Adaptive Response to a High Salt Diet
Joint Authors
Correa, Alicia
Cao, Gabriel
Gorzalczany, Susana
Zotta, Elsa
Cerrudo, Carolina Susana
Rosón, María Inés
Trida, Verónica
Toblli, Jorge Eduardo
Della Penna, Silvana Lorena
Rukavina Mikusic, Natalia Lucía
Carranza, Andrea
Fernández, Belisario Enrique
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In the kidney, a high salt intake favors oxidative stress and hypoxia and causes the development of fibrosis.
Both atrial natriuretic peptide (ANP) and hypoxia inducible factor (HIF-1α) exert cytoprotective effects.
We tested the hypothesis that renal expression of ANP and HIF-1α is involved in a mechanism responding to the oxidative stress produced in the kidneys of rats chronically fed a high sodium diet.
Sprague-Dawley rats were fed with a normal salt (0.4% NaCl) (NS) or a high salt (8% NaCl) (HS) diet for 3 weeks, with or without the administration of tempol (T), an inhibitor of oxidative stress, in the drinking water.
We measured the mean arterial pressure (MAP), glomerular filtration rate (GFR), and urinary sodium excretion (UVNa).
We evaluated the expression of ANP, HIF-1α, and transforming growth factor (TGF-β1) in renal tissues by western blot and immunohistochemistry.
The animals fed a high salt diet showed increased MAP and UVNa levels and enhanced renal immunostaining of ANP, HIF-1α, and TGF-β1.
The administration of tempol together with the sodium overload increased the natriuresis further and prevented the elevation of blood pressure and the increased expression of ANP, TGF-β1, and HIF-1α compared to their control.
These findings suggest that HIF-1α and ANP, synthesized by the kidney, are involved in an adaptive mechanism in response to a sodium overload to prevent or attenuate the deleterious effects of the oxidative stress and the hypoxia on the development of fibrosis.
American Psychological Association (APA)
Della Penna, Silvana Lorena& Cao, Gabriel& Carranza, Andrea& Zotta, Elsa& Gorzalczany, Susana& Cerrudo, Carolina Susana…[et al.]. 2014. Renal Overexpression of Atrial Natriuretic Peptide and Hypoxia Inducible Factor-1α as Adaptive Response to a High Salt Diet. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-509621
Modern Language Association (MLA)
Della Penna, Silvana Lorena…[et al.]. Renal Overexpression of Atrial Natriuretic Peptide and Hypoxia Inducible Factor-1α as Adaptive Response to a High Salt Diet. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-509621
American Medical Association (AMA)
Della Penna, Silvana Lorena& Cao, Gabriel& Carranza, Andrea& Zotta, Elsa& Gorzalczany, Susana& Cerrudo, Carolina Susana…[et al.]. Renal Overexpression of Atrial Natriuretic Peptide and Hypoxia Inducible Factor-1α as Adaptive Response to a High Salt Diet. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-509621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509621