The Effect of Chinese Herbal Medicine on Albuminuria Levels in Patients with Diabetic Nephropathy : A Systematic Review and Meta-Analysis
Joint Authors
Xiao, Ya
Li, Fei
Zhao, Xiaoshan
Liu, Yanyan
Yu, Keqiang
Luo, Ren
Bi, Jianlu
Cheng, Jingru
Zhou, Lin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
To evaluate the effect of Chinese herbal medicine (CHM) on albuminuria levels in patients with diabetic nephropathy (DN), we performed comprehensive searches on Medline database, Cochrane Library, CNKI database, CBM database, Wanfang database, and VIP database up to December 2012.
A total of 29 trials including 2440 participants with DN met the selection criteria.
CHM was tested to be more effective in reducing urinary albumin excretion rate (UAER) (MD −82.95 μg/min, [−138.64, −27.26]) and proteinuria (MD −565.99 mg/24 h, [−892.41, −239.57]) compared with placebo.
CHM had a greater beneficial effect on reduction of UAER (MD −13.41 μg/min, [−20.63, −6.19]) and proteinuria (MD −87.48 mg/24 h, [−142.90, −32.06]) compared with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB).
Combination therapy with CHM and ACEI/ARB showed significant improvement in UAER (MD −28.18 μg/min, [−44.4, −11.97]), urinary albumin-creatinine ratio (MD −347.00, [−410.61, −283.39]), protein-creatinine ratio (MD −2.49, [−4.02, −0.96]), and proteinuria (MD −26.60 mg/24 h, [−26.73, −26.47]) compared with ACEI/ARB alone.
No serious adverse events were reported.
CHM seems to be an effective and safe therapy option to treat proteinuric patients with DN, suggesting that further study of CHM in the treatment of DN is warranted in rigorously designed, multicentre, large-scale trials with higher quality worldwide.
American Psychological Association (APA)
Xiao, Ya& Liu, Yanyan& Yu, Keqiang& Zhou, Lin& Bi, Jianlu& Cheng, Jingru…[et al.]. 2013. The Effect of Chinese Herbal Medicine on Albuminuria Levels in Patients with Diabetic Nephropathy : A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-509671
Modern Language Association (MLA)
Xiao, Ya…[et al.]. The Effect of Chinese Herbal Medicine on Albuminuria Levels in Patients with Diabetic Nephropathy : A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-509671
American Medical Association (AMA)
Xiao, Ya& Liu, Yanyan& Yu, Keqiang& Zhou, Lin& Bi, Jianlu& Cheng, Jingru…[et al.]. The Effect of Chinese Herbal Medicine on Albuminuria Levels in Patients with Diabetic Nephropathy : A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-509671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509671