Point-of-Care Tests for Bladder Cancer : The Influencing Role of Hematuria
Joint Authors
Kuehs, Ursula
Schwentner, Christian
Stenzl, Arnulf
Hennenlotter, Joerg
Todenhöfer, Tilman
Schilling, David
Gakis, Georgios
Huber, Severine
Aufderklamm, Stefan
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Several point-of-care tests (POCT) are available for the diagnosis of bladder cancer (BC).
We evaluate the impact of HU (hematuria) on performance of POCTs.
Materials and Methods.
Urine from 10 donors was diluted with blood from 0.5 to 0.00625%.
BladderCheckR, BTAstatR, BCMR, and BTAR tests were applied.
Tests were additionally conducted in 54 patients with HU.
HU was stratified according to the amount of erythrocytes (RBC)/μL using two systems: (1) no HU; mild microscopic HU; severe microscopic HU; gross HU; (2) I <25 RBCs; <250 II; ≥250 III.
Results were compared to HU status and histopathology.
Results.
Gross HU became evident between 2090 RBCs/μL and 1065/μL.
Addition of blood led to default tests in all 4: BladderCheckR 0.25%; BCM 0.025%, BioNexia 0.00625%, and BTAstat <0.00625%.
Rates of false positives for BladderCheck, BTAstat, BCM, and BioNexia were 5.9, 11.8, 0, and 1.8% without HU and 0, 66.7, 44.4, and 66.7% with HU.
BTAstat, BCM, and BioNexia were independently influenced by HU (P<0.0002).
Conclusions.
NMP22-BladderCheck was most resistant to blood.
The diagnostic yield of all others was significantly influenced by HU.
A well-defined HU grading helps to define limits of HU for a reliable interpretation of BC-POCTs.
American Psychological Association (APA)
Hennenlotter, Joerg& Huber, Severine& Todenhöfer, Tilman& Kuehs, Ursula& Schilling, David& Aufderklamm, Stefan…[et al.]. 2011. Point-of-Care Tests for Bladder Cancer : The Influencing Role of Hematuria. Advances in Urology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-509672
Modern Language Association (MLA)
Hennenlotter, Joerg…[et al.]. Point-of-Care Tests for Bladder Cancer : The Influencing Role of Hematuria. Advances in Urology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-509672
American Medical Association (AMA)
Hennenlotter, Joerg& Huber, Severine& Todenhöfer, Tilman& Kuehs, Ursula& Schilling, David& Aufderklamm, Stefan…[et al.]. Point-of-Care Tests for Bladder Cancer : The Influencing Role of Hematuria. Advances in Urology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-509672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509672