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An Overview of Molecular Mechanism of Nephrotic Syndrome
Joint Authors
Castellano, Lúcio Roberto
Corrêa, Rosana Rosa Miranda
Rocha, Laura Penna
Neves, Precil Diego Miranda de Menezes
Silva, Marcos Vinícius
Reis, Marlene Antônia dos
Machado, Juliana Reis
de Castro Côbo, Eliângela
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Podocytopathies (minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS)) together with membranous nephropathy are the main causes of nephrotic syndrome.
Some changes on the expression of nephrin, podocin, TGF-β, and slit diaphragm components as well as transcription factors and transmembrane proteins have been demonstrated in podocytopathies.
Considering the pathogenesis of proteinuria, some elucidations have been directed towards the involvement of epithelial-mesenchymal transition.
Moreover, the usefulness of some markers such as TGF-β1, nephrin, synaptopodin, dystroglycans, and malondialdehyde have been determined in the differentiation between MCD and FSGS.
Experimental models and human samples indicated an essential role of autoantibodies in membranous glomerulonephritis, kidney damage, and proteinuria events.
Megalin and phospholipase-A2-receptor have been described as antigens responsible for the formation of the subepithelial immune complexes and renal disease occurrence.
In addition, the complement system seems to play a key role in basal membrane damage and in the development of proteinuria in membranous nephropathy.
This paper focuses on the common molecular changes involved in the development of nephrotic proteinuria.
American Psychological Association (APA)
Machado, Juliana Reis& Rocha, Laura Penna& Neves, Precil Diego Miranda de Menezes& de Castro Côbo, Eliângela& Silva, Marcos Vinícius& Castellano, Lúcio Roberto…[et al.]. 2012. An Overview of Molecular Mechanism of Nephrotic Syndrome. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-509683
Modern Language Association (MLA)
Machado, Juliana Reis…[et al.]. An Overview of Molecular Mechanism of Nephrotic Syndrome. International Journal of Nephrology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-509683
American Medical Association (AMA)
Machado, Juliana Reis& Rocha, Laura Penna& Neves, Precil Diego Miranda de Menezes& de Castro Côbo, Eliângela& Silva, Marcos Vinícius& Castellano, Lúcio Roberto…[et al.]. An Overview of Molecular Mechanism of Nephrotic Syndrome. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-509683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509683