Montanoa frutescens and Montanoa grandiflora Extracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats
Joint Authors
Rodríguez-Landa, Juan Francisco
García-Orduña, Francisco
Rodríguez-Blanco, Luis Alfredo
Carro-Juárez, Miguel
Vicente-Serna, Julio
Rovirosa-Hernández, María de Jesús
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In previous studies, the anxiolytic-like effects of Montanoa tomentosa and Montanoa frutescens were reported in male rats, but the potential anxiolytic-like effects of Montanoa plants during the different phases of the ovarian cycle in rats remain to be explored.
The anxiolytic-like effects of the aqueous crude extracts of M.
frutescens (25 and 50 mg/kg) and M.
grandiflora (25 and 50 mg/kg) in the elevated plus maze were investigated in Wistar rats during the estrous cycle and compared with 2 mg/kg diazepam as a reference anxiolytic drug.
To investigate any motor effect (i.e., hyperactivity, no changes, or hypoactivity) associated with the treatments, the rats were evaluated in the open field test.
The M.
frutescens (25 and 50 mg/kg) and M.
grandiflora (50 mg/kg) extracts exerted anxiolytic-like effects during the metestrus-diestrus phase, similar to diazepam, without disrupting spontaneous motor activity.
No significant effects of the extracts were detected in either behavioral test during the proestrus-estrus phase, whereas diazepam produced motor hypoactivity in the open field test.
These results indicate that the M.
frutescens and M.
grandiflora extracts possess anxiolytic-like effects that depend on the ovarian cycle phase, supporting the Mexican ancient medicinal use of these plants to ameliorate anxiety disorders.
American Psychological Association (APA)
Rodríguez-Landa, Juan Francisco& Vicente-Serna, Julio& Rodríguez-Blanco, Luis Alfredo& Rovirosa-Hernández, María de Jesús& García-Orduña, Francisco& Carro-Juárez, Miguel. 2014. Montanoa frutescens and Montanoa grandiflora Extracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-509718
Modern Language Association (MLA)
Rodríguez-Landa, Juan Francisco…[et al.]. Montanoa frutescens and Montanoa grandiflora Extracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-509718
American Medical Association (AMA)
Rodríguez-Landa, Juan Francisco& Vicente-Serna, Julio& Rodríguez-Blanco, Luis Alfredo& Rovirosa-Hernández, María de Jesús& García-Orduña, Francisco& Carro-Juárez, Miguel. Montanoa frutescens and Montanoa grandiflora Extracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-509718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509718