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Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and AktBad14-3-3γ in an Experimental Animal Model
Joint Authors
Lee, Huei-Jane
Lee, Wen-Chin
Wang, Shou-Chieh
Lee, Shiow-Fen
Lee, Chen-Hsen
Wang, Chau-Jong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several studies point out that oxidative stress maybe a major culprit in diabetic nephropathy.
Aqueous extract of Hibiscus sabdariffa L.
(HSE) has been demonstrated as having beneficial effects on anti-oxidation and lipid-lowering in experimental studies.
This study aimed at investigating the effects of Hibiscus sabdariffa L.
on diabetic nephropathy in streptozotocin induced type 1 diabetic rats.
Our results show that HSE is capable of reducing lipid peroxidation, increasing catalase and glutathione activities significantly in diabetic kidney, and decreasing the plasma levels of triglyceride, low-density lipoprotein (LDL) and increasing high-density lipoprotein (HDL) value.
In histological examination, HSE improves hyperglycemia-caused osmotic diuresis in renal proximal convoluted tubules (defined as hydropic change) in diabetic rats.
The study also reveals that up-regulation of Akt/Bad/14-3-3γ and NF-κB-mediated transcription might be involved.
In conclusion, our results show that HSE possesses the potential effects to ameliorate diabetic nephropathy via improving oxidative status and regulating Akt/Bad/14-3-3γ signaling.
American Psychological Association (APA)
Wang, Shou-Chieh& Lee, Shiow-Fen& Wang, Chau-Jong& Lee, Chen-Hsen& Lee, Wen-Chin& Lee, Huei-Jane. 2011. Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and AktBad14-3-3γ in an Experimental Animal Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-509722
Modern Language Association (MLA)
Wang, Shou-Chieh…[et al.]. Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and AktBad14-3-3γ in an Experimental Animal Model. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-509722
American Medical Association (AMA)
Wang, Shou-Chieh& Lee, Shiow-Fen& Wang, Chau-Jong& Lee, Chen-Hsen& Lee, Wen-Chin& Lee, Huei-Jane. Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and AktBad14-3-3γ in an Experimental Animal Model. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-509722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509722