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Graph-Theoretic Models of Mutations in the Nucleotide Binding Domain 1 of the Cystic Fibrosis Transmembrane Conductance Regulator
Joint Authors
Herron, Andrew Cade
Knisley, Jeff R.
Knisley, Debra J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cystic fibrosis is one of the most common inherited diseases and is caused by a mutation in a membrane protein, the cystic fibrosis transmembrane conductance regulator (CFTR).
This protein serves as a chloride channel and regulates the viscosity of mucus lining the ducts of a number of organs.
Although much has been learned about the consequences of mutations on the energy landscape and the resulting disrupted folding pathway of CFTR, a level of understanding needed to correct the misfolding has not been achieved.
The most common mutations of CFTR are located in one of two nucleotide binding domains, namely, the nucleotide binding domain 1 (NBD1).
We model NBD1 using a nested graph model.
The vertices in the lowest layer each represent an atom in the structure of an amino acid residue, while the vertices in the mid layer each represent the residue.
The vertices in the top layer each represent a subdomain of the nucleotide binding domain.
We use this model to quantify the effects of a single point mutation on the protein domain.
We compare the wildtype structure with eight of the most common mutations.
The graph-theoretic model provides insight into how a single point mutation can have such profound structural consequences.
American Psychological Association (APA)
Knisley, Debra J.& Knisley, Jeff R.& Herron, Andrew Cade. 2013. Graph-Theoretic Models of Mutations in the Nucleotide Binding Domain 1 of the Cystic Fibrosis Transmembrane Conductance Regulator. Computational Biology Journal،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-509728
Modern Language Association (MLA)
Knisley, Debra J.…[et al.]. Graph-Theoretic Models of Mutations in the Nucleotide Binding Domain 1 of the Cystic Fibrosis Transmembrane Conductance Regulator. Computational Biology Journal No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-509728
American Medical Association (AMA)
Knisley, Debra J.& Knisley, Jeff R.& Herron, Andrew Cade. Graph-Theoretic Models of Mutations in the Nucleotide Binding Domain 1 of the Cystic Fibrosis Transmembrane Conductance Regulator. Computational Biology Journal. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-509728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509728