Low Occurrence of Tuberculosis Drug Resistance among Pulmonary Tuberculosis Patients from an Urban Setting, with a Long-Running DOTS Program in Zambia
Joint Authors
Shamputa, Isdore Chola
Bwalya, Innocent C.
Mulenga, Chanda
Chonde, Allan
Fissette, Krista
Kapata, Nathan
Portaels, Françoise
Rigouts, Leen
Kakungu-Simpungwe, Mathilda
Docx, Sven
Source
Tuberculosis Research and Treatment
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We set out to determine the levels of Mycobacterium tuberculosis resistance to first- and second-line TB drugs in an urban population in Zambia.
Sputum samples were collected consecutively from all smear-positive, new and previously treated patients, from four diagnostic centres in Ndola between January and July 2006.
Drug susceptibility testing was performed using the proportion method against four first- and two second-line TB drugs.
Results.
Among 156 new cases, any resistance was observed to be 7.7%, monoresistance to isoniazid and rifampicin was 4.5% and 1.3%, respectively.
Of 31 retreatment cases, any resistance was observed to be 16.1%, monoresistance to isoniazid and rifampicin was 3.3% for each drug, and one case of resistance to both isoniazid and rifampicin (multidrug resistance) was detected.
No resistance to kanamycin or ofloxacin was detected.
Conclusion.
Although not representative of the country, these results show low levels of drug resistance in a community with a long-standing DOTS experience.
Resource constrained countries may reduce TB drug resistance by implementing community-based strategies that enhance treatment completion.
American Psychological Association (APA)
Mulenga, Chanda& Chonde, Allan& Bwalya, Innocent C.& Kapata, Nathan& Kakungu-Simpungwe, Mathilda& Docx, Sven…[et al.]. 2010. Low Occurrence of Tuberculosis Drug Resistance among Pulmonary Tuberculosis Patients from an Urban Setting, with a Long-Running DOTS Program in Zambia. Tuberculosis Research and Treatment،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-509729
Modern Language Association (MLA)
Mulenga, Chanda…[et al.]. Low Occurrence of Tuberculosis Drug Resistance among Pulmonary Tuberculosis Patients from an Urban Setting, with a Long-Running DOTS Program in Zambia. Tuberculosis Research and Treatment No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-509729
American Medical Association (AMA)
Mulenga, Chanda& Chonde, Allan& Bwalya, Innocent C.& Kapata, Nathan& Kakungu-Simpungwe, Mathilda& Docx, Sven…[et al.]. Low Occurrence of Tuberculosis Drug Resistance among Pulmonary Tuberculosis Patients from an Urban Setting, with a Long-Running DOTS Program in Zambia. Tuberculosis Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-509729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509729