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Functional Diversification of Fungal Glutathione Transferases from the Ure2p Class
Joint Authors
Thion, Cécile
Billard, Patrick
Ngadin, Andrew A.
Gelhaye, Eric
Jacquot, Jean-Pierre
Thuillier, Anne
Morel, Mélanie
Source
International Journal of Evolutionary Biology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The glutathione-S-transferase (GST) proteins represent an extended family involved in detoxification processes.
They are divided into various classes with high diversity in various organisms.
The Ure2p class is especially expanded in saprophytic fungi compared to other fungi.
This class is subdivided into two subclasses named Ure2pA and Ure2pB, which have rapidly diversified among fungal phyla.
We have focused our analysis on Basidiomycetes and used Phanerochaete chrysosporium as a model to correlate the sequence diversity with the functional diversity of these glutathione transferases.
The results show that among the nine isoforms found in P.
chrysosporium, two belonging to Ure2pA subclass are exclusively expressed at the transcriptional level in presence of polycyclic aromatic compounds.
Moreover, we have highlighted differential catalytic activities and substrate specificities between Ure2pA and Ure2pB isoforms.
This diversity of sequence and function suggests that fungal Ure2p sequences have evolved rapidly in response to environmental constraints.
American Psychological Association (APA)
Thuillier, Anne& Ngadin, Andrew A.& Thion, Cécile& Billard, Patrick& Jacquot, Jean-Pierre& Gelhaye, Eric…[et al.]. 2011. Functional Diversification of Fungal Glutathione Transferases from the Ure2p Class. International Journal of Evolutionary Biology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-509746
Modern Language Association (MLA)
Thuillier, Anne…[et al.]. Functional Diversification of Fungal Glutathione Transferases from the Ure2p Class. International Journal of Evolutionary Biology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-509746
American Medical Association (AMA)
Thuillier, Anne& Ngadin, Andrew A.& Thion, Cécile& Billard, Patrick& Jacquot, Jean-Pierre& Gelhaye, Eric…[et al.]. Functional Diversification of Fungal Glutathione Transferases from the Ure2p Class. International Journal of Evolutionary Biology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-509746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509746