A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment : Predicting Potential New Drugs and Targets
Joint Authors
Liu, Jianling
Zheng, Chunli
Li, Yan
Pei, Mengjie
Yang, Ling
Lu, Ai-ping
Wang, Yonghua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-28
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
For thousands of years, tonic herbs have been successfully used all around the world to improve health, energy, and vitality.
However, their underlying mechanisms of action in molecular/systems levels are still a mystery.
In this work, two sets of tonic herbs, so called Qi-enriching herbs (QEH) and Blood-tonifying herbs (BTH) in TCM, were selected to elucidate why they can restore proper balance and harmony inside body, organ and energy system.
Firstly, a pattern recognition model based on artificial neural network and discriminant analysis for assessing the molecular difference between QEH and BTH was developed.
It is indicated that QEH compounds have high lipophilicity while BTH compounds possess high chemical reactivity.
Secondly, a systematic investigation integrating ADME (absorption, distribution, metabolism, and excretion) prediction, target fishing and network analysis was performed and validated on these herbs to obtain the compound-target associations for reconstructing the biologically-meaningful networks.
The results suggest QEH enhance physical strength, immune system and normal well-being, acting as adjuvant therapy for chronic disorders while BTH stimulate hematopoiesis function in body.
As an emerging approach, the systems pharmacology model might facilitate to understand the mechanisms of action of the tonic herbs, which brings about new development for complementary and alternative medicine.
American Psychological Association (APA)
Liu, Jianling& Pei, Mengjie& Zheng, Chunli& Li, Yan& Wang, Yonghua& Lu, Ai-ping…[et al.]. 2013. A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment : Predicting Potential New Drugs and Targets. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-509789
Modern Language Association (MLA)
Liu, Jianling…[et al.]. A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment : Predicting Potential New Drugs and Targets. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-509789
American Medical Association (AMA)
Liu, Jianling& Pei, Mengjie& Zheng, Chunli& Li, Yan& Wang, Yonghua& Lu, Ai-ping…[et al.]. A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment : Predicting Potential New Drugs and Targets. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-509789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509789