Retinoid Differentiation Therapy for Common Types of Acute Myeloid Leukemia
Joint Authors
Hughes, Philip J.
Brown, Geoffrey
Source
Leukemia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
Many cancers arise in a tissue stem cell, and cell differentiation is impaired resulting in an accumulation of immature cells.
The introduction of all-trans retinoic acid (ATRA) in 1987 to treat acute promyelocytic leukemia (APL), a rare subtype of acute myeloid leukemia (AML), pioneered a new approach to obtain remission in malignancies by restoring the terminal maturation of leukemia cells resulting in these cells having a limited lifespan.
Differentiation therapy also offers the prospect of a less aggressive treatment by virtue of attenuated growth of leukemia cells coupled to limited damage to normal cells.
The success of ATRA in differentiation therapy of APL is well known.
However, ATRA does not work in non-APL AML.
Here we examine some of the molecular pathways towards new retinoid-based differentiation therapy of non-APL AML.
Prospects include modulation of the epigenetic status of ATRA-insensitive AML cells, agents that influence intracellular signalling events that are provoked by ATRA, and the use of novel synthetic retinoids.
American Psychological Association (APA)
Brown, Geoffrey& Hughes, Philip J.. 2012. Retinoid Differentiation Therapy for Common Types of Acute Myeloid Leukemia. Leukemia Research and Treatment،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-509802
Modern Language Association (MLA)
Brown, Geoffrey& Hughes, Philip J.. Retinoid Differentiation Therapy for Common Types of Acute Myeloid Leukemia. Leukemia Research and Treatment No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-509802
American Medical Association (AMA)
Brown, Geoffrey& Hughes, Philip J.. Retinoid Differentiation Therapy for Common Types of Acute Myeloid Leukemia. Leukemia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-509802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509802