Evolution of Hepatitis B Virus in a Chronic HBV-Infected Patient over 2 Years
Joint Authors
Wang, Lin-Pin
Zuo, Rong-Xia
Yan, Xin-Min
Wang, Jin-Li
Shen, Tao
Zhang, Jin-Ping
Li, Li
Source
Hepatitis Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Mutations in full-length HBV isolates obtained from a chronic HBV-infected patient were evaluated at three time points: 1 day, 6 months, and 31 months.
While 5 nucleotides variation, and an 18 bp deletion of preS1 have been kept in during at least the first two years, C339T mutation occurring in the hydrophilic region of HBsAg and T770C that caused polymerase V560A substitution were the new point mutations found existing in sequenced clones of the 3rd time point.
Internal deletion of coding region obviously appeared in the 3rd time point.
The splicers included two new 5′-splice donors and three new 3′-splice acceptors besides the reported donors and acceptors and may have produced presumptive HBV-spliced proteins or truncated preS proteins.
ALT, HBeAg and viral DNA load varied during the follow-up years.
These data demonstrated the diversity of genomes in HBV-infected patient during evolution.
Combined with clinical data, the HBV variants discovered in this patient may contribute to viral persistence of infection or liver pathogenesis.
American Psychological Association (APA)
Shen, Tao& Yan, Xin-Min& Zhang, Jin-Ping& Wang, Jin-Li& Zuo, Rong-Xia& Li, Li…[et al.]. 2011. Evolution of Hepatitis B Virus in a Chronic HBV-Infected Patient over 2 Years. Hepatitis Research and Treatment،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-509811
Modern Language Association (MLA)
Shen, Tao…[et al.]. Evolution of Hepatitis B Virus in a Chronic HBV-Infected Patient over 2 Years. Hepatitis Research and Treatment No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-509811
American Medical Association (AMA)
Shen, Tao& Yan, Xin-Min& Zhang, Jin-Ping& Wang, Jin-Li& Zuo, Rong-Xia& Li, Li…[et al.]. Evolution of Hepatitis B Virus in a Chronic HBV-Infected Patient over 2 Years. Hepatitis Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-509811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509811