B-Cell-Activating Factor and Autoimmune Myasthenia Gravis
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
BAFF is a potent B-cell survival factor, and it plays an essential role in B-cell homeostasis and B-cell function in the periphery.
Both normal and autoreactive B cells are BAFF dependent; however, excess BAFF promotes the survival, growth, and maturation of autoreactive B cells.
When overexpressed, BAFF protects B cells from apoptosis, thereby contributing to autoimmunity.
Three independent studies have shown higher BAFF levels in the circulation of MG patients.
BAFF may play an important role in the pathogenesis of MG.
BAFF antagonists may well provide new treatment options for MG patients, particularly those patients with thymic lymphoid follicular hyperplasia.
American Psychological Association (APA)
Ragheb, Samia& Lisak, Robert P.. 2011. B-Cell-Activating Factor and Autoimmune Myasthenia Gravis. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-509839
Modern Language Association (MLA)
Ragheb, Samia& Lisak, Robert P.. B-Cell-Activating Factor and Autoimmune Myasthenia Gravis. Autoimmune Diseases No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-509839
American Medical Association (AMA)
Ragheb, Samia& Lisak, Robert P.. B-Cell-Activating Factor and Autoimmune Myasthenia Gravis. Autoimmune Diseases. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-509839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509839