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Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress
Joint Authors
Ponugoti, Bhaskar
Dong, Guangyu
Graves, Dana T.
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetes is a chronic metabolic disorder, characterized by hyperglycemia resulting from insulin deficiency and/or insulin resistance.
Recent evidence suggests that high levels of reactive oxygen species (ROS) and subsequent oxidative stress are key contributors in the development of diabetic complications.
The FOXO family of forkhead transcription factors including FOXO1, FOXO3, FOXO4, and FOXO6 play important roles in the regulation of many cellular and biological processes and are critical regulators of cellular oxidative stress response pathways.
FOXO1 transcription factors can affect a number of different tissues including liver, retina, bone, and cell types ranging from hepatocytes to microvascular endothelial cells and pericytes to osteoblasts.
They are induced by oxidative stress and contribute to ROS-induced cell damage and apoptosis.
In this paper, we discuss the role of FOXO transcription factors in mediating oxidative stress-induced cellular response.
American Psychological Association (APA)
Ponugoti, Bhaskar& Dong, Guangyu& Graves, Dana T.. 2012. Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-509859
Modern Language Association (MLA)
Ponugoti, Bhaskar…[et al.]. Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-509859
American Medical Association (AMA)
Ponugoti, Bhaskar& Dong, Guangyu& Graves, Dana T.. Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-509859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509859