A Review on Composite Liposomal Technologies for Specialized Drug Delivery
Joint Authors
du Toit, Lisa C.
Pillay, Viness
Modi, Girish
Naidoo, Dinesh
Mufamadi, Maluta S.
Ndesendo, Valence M. K.
Choonara, Yahya E.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-08
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
The combination of liposomes with polymeric scaffolds could revolutionize the current state of drug delivery technology.
Although liposomes have been extensively studied as a promising drug delivery model for bioactive compounds, there still remain major drawbacks for widespread pharmaceutical application.
Two approaches for overcoming the factors related to the suboptimal efficacy of liposomes in drug delivery have been suggested.
The first entails modifying the liposome surface with functional moieties, while the second involves integration of pre-encapsulated drug-loaded liposomes within depot polymeric scaffolds.
This attempts to provide ingenious solutions to the limitations of conventional liposomes such as short plasma half-lives, toxicity, stability, and poor control of drug release over prolonged periods.
This review delineates the key advances in composite technologies that merge the concepts of depot polymeric scaffolds with liposome technology to overcome the limitations of conventional liposomes for pharmaceutical applications.
American Psychological Association (APA)
Mufamadi, Maluta S.& Pillay, Viness& Choonara, Yahya E.& du Toit, Lisa C.& Modi, Girish& Naidoo, Dinesh…[et al.]. 2011. A Review on Composite Liposomal Technologies for Specialized Drug Delivery. Journal of Drug Delivery،Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-509870
Modern Language Association (MLA)
Mufamadi, Maluta S.…[et al.]. A Review on Composite Liposomal Technologies for Specialized Drug Delivery. Journal of Drug Delivery No. 2011 (2011), pp.1-19.
https://search.emarefa.net/detail/BIM-509870
American Medical Association (AMA)
Mufamadi, Maluta S.& Pillay, Viness& Choonara, Yahya E.& du Toit, Lisa C.& Modi, Girish& Naidoo, Dinesh…[et al.]. A Review on Composite Liposomal Technologies for Specialized Drug Delivery. Journal of Drug Delivery. 2011. Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-509870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509870