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Hemin Augments Growth and Hemoglobinization of Erythroid Precursors from Patients with Diamond-Blackfan Anemia
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-13
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Diamond-Blackfan anemia (DBA) is congenital pure red-cell anemia due to a differentiation block in erythroid precursors.
The disease is commonly caused by mutations in genes for ribosomal proteins.
Despite the identification of disease causal genes, the disease pathogenesis is not completely elucidated.
The ribosomal abnormalities are assumed to inhibit globin translation which may lead to excess free heme, stimulating a generation of free radicals and thereby damaging the precursors.
We studied the effect of hemin (heme chloride) on cultured human erythroid precursors and found that contrary to aforementioned hypothesis, although hemin moderately stimulated free radicals, it did not cause apoptosis or necrosis.
In erythroid precursors derived from DBA patients, hemin significantly stimulated growth and hemoglobinization.
Thus, heme toxicity is unlikely to play a role in the pathophysiology of most DBA cases.
Moreover, its beneficial effect in culture suggests a therapeutic potential.
American Psychological Association (APA)
Fibach, Eitan& Aker, Memet. 2012. Hemin Augments Growth and Hemoglobinization of Erythroid Precursors from Patients with Diamond-Blackfan Anemia. Anemia،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-509893
Modern Language Association (MLA)
Fibach, Eitan& Aker, Memet. Hemin Augments Growth and Hemoglobinization of Erythroid Precursors from Patients with Diamond-Blackfan Anemia. Anemia No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-509893
American Medical Association (AMA)
Fibach, Eitan& Aker, Memet. Hemin Augments Growth and Hemoglobinization of Erythroid Precursors from Patients with Diamond-Blackfan Anemia. Anemia. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-509893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509893