Peroxisome Proliferator-Activated Receptor Gamma Exacerbates Concanavalin A-Induced Liver Injury via Suppressing the Translocation of NF-κB into the Nucleus
Joint Authors
Ogawa, Yuji
Tomeno, Wataru
Fujita, Koji
Wada, Koichiro
Yoneda, Masato
Kirikoshi, Hiroyuki
Imajo, Kento
Nakajima, Atsushi
Saito, Satoru
Maeda, Shin
Shibata, Wataru
Shinohara, Yoshiyasu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to reduce inflammation and attenuate fibrosis in the liver.
In this study, we investigated the effects of PPARγ on the liver injury induced by 20 mg/kg Concanavalin A (Con A).
The mice were administered one of the three types of PPARγ ligands (pioglitazone, ciglitazone, and troglitazone) for 1 week, and the serum alanine aminotransferase (ALT) levels at 20 h after Con A injection were significantly elevated in the PPARγ ligand-treated mice.
Furthermore, the serum ALT levels after Con A injection in the PPARγ hetero-knock-out mice (PPARγ+/− mice) were lower than those in the wild-type mice (WT mice).
Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) revealed extensive liver damage induced by Con A in the pioglitazone-treated mice.
Electrophoresis mobility shift assay (EMSA) revealed that activation of translocation of nuclear factor- (NF-) κB, which is a suppressor of apoptosis, in the nucleus of the hepatocytes was suppressed in the pioglitazone-treated mice after Con A injection.
In this study, we showed that PPARγ exacerbated Con A-induced liver injury via suppressing the translocation of NF-κB into the nucleus, thereby inhibiting the suppression of liver cell apoptosis.
American Psychological Association (APA)
Ogawa, Yuji& Yoneda, Masato& Tomeno, Wataru& Imajo, Kento& Shinohara, Yoshiyasu& Fujita, Koji…[et al.]. 2012. Peroxisome Proliferator-Activated Receptor Gamma Exacerbates Concanavalin A-Induced Liver Injury via Suppressing the Translocation of NF-κB into the Nucleus. PPAR Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-509910
Modern Language Association (MLA)
Ogawa, Yuji…[et al.]. Peroxisome Proliferator-Activated Receptor Gamma Exacerbates Concanavalin A-Induced Liver Injury via Suppressing the Translocation of NF-κB into the Nucleus. PPAR Research No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-509910
American Medical Association (AMA)
Ogawa, Yuji& Yoneda, Masato& Tomeno, Wataru& Imajo, Kento& Shinohara, Yoshiyasu& Fujita, Koji…[et al.]. Peroxisome Proliferator-Activated Receptor Gamma Exacerbates Concanavalin A-Induced Liver Injury via Suppressing the Translocation of NF-κB into the Nucleus. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-509910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509910