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Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer
Joint Authors
Johnson, Jackie L.
Pillai, Smitha
Chellappan, Srikumar P.
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-15
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Despite significant advances in the detection and treatment of lung cancer, it causes the highest number of cancer-related mortality.
Recent advances in the detection of genetic alterations in patient samples along with physiologically relevant animal models has yielded a new understanding of the molecular etiology of lung cancer.
This has facilitated the development of potent and specific targeted therapies, based on the genetic and biochemical alterations present in the tumor, especially non-small-cell lung cancer (NSCLC).
It is now clear that heterogeneous cell signaling pathways are disrupted to promote NSCLC, including mutations in critical growth regulatory proteins (K-Ras, EGFR, B-RAF, MEK-1, HER2, MET, EML-4-ALK, KIF5B-RET, and NKX2.1) and inactivation of growth inhibitory pathways (TP53, PTEN, p16, and LKB-1).
How these pathways differ between smokers and non-smokers is also important for clinical treatment strategies and development of targeted therapies.
This paper describes these molecular targets in NSCLC, and describes the biological significance of each mutation and their potential to act as a therapeutic target.
American Psychological Association (APA)
Johnson, Jackie L.& Pillai, Smitha& Chellappan, Srikumar P.. 2012. Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-509913
Modern Language Association (MLA)
Johnson, Jackie L.…[et al.]. Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer. Biochemistry Research International No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-509913
American Medical Association (AMA)
Johnson, Jackie L.& Pillai, Smitha& Chellappan, Srikumar P.. Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-509913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509913