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Eupomatenoid-5 Isolated from Leaves of Piper regnellii Induces Apoptosis in Leishmania amazonensis
Joint Authors
Lazarin-Bidóia, Danielle
Garcia, Francielle Pelegrin
Ueda-Nakamura, Tânia
Silva, Sueli de Oliveira
Nakamura, Celso Vataru
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Leishmania spp.
are protozoa responsible for leishmaniasis, a neglected disease that kills up to 50,000 people every year.
Current therapies mainly rely on antimonial drugs that are inadequate because of their poor efficacy and safety and increased drug resistance.
An urgent need exists to find new and more affordable drugs.
Our previous study demonstrated the antileishmanial activity of eupomatenoid-5, a neolignan obtained from leaves of Piper regnellii var.
pallescens.
The aim of the present study was to clarify the mode of action of eupomatenoid-5 against L.
amazonensis.
We used biochemical and morphological techniques and demonstrated that eupomatenoid-5 induced cell death in L.
amazonensis promastigotes, sharing some phenotypic features observed in metazoan apoptosis, including increased reactive oxygen species production, hypopolarization of mitochondrial potential, phosphatidylserine exposure, decreased cell volume, and G0/G1 phase cell cycle arrest.
American Psychological Association (APA)
Garcia, Francielle Pelegrin& Lazarin-Bidóia, Danielle& Ueda-Nakamura, Tânia& Silva, Sueli de Oliveira& Nakamura, Celso Vataru. 2013. Eupomatenoid-5 Isolated from Leaves of Piper regnellii Induces Apoptosis in Leishmania amazonensis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-509924
Modern Language Association (MLA)
Garcia, Francielle Pelegrin…[et al.]. Eupomatenoid-5 Isolated from Leaves of Piper regnellii Induces Apoptosis in Leishmania amazonensis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-509924
American Medical Association (AMA)
Garcia, Francielle Pelegrin& Lazarin-Bidóia, Danielle& Ueda-Nakamura, Tânia& Silva, Sueli de Oliveira& Nakamura, Celso Vataru. Eupomatenoid-5 Isolated from Leaves of Piper regnellii Induces Apoptosis in Leishmania amazonensis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-509924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509924