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The Host Genetic Diversity in Malaria Infection
Joint Authors
Barral-Netto, Manoel
Goncalves, Marilda Souza
de Mendonça, Vitor R. R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-13
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Populations exposed to Plasmodium infection develop genetic mechanisms of protection against severe disease.
The clinical manifestation of malaria results primarily from the lysis of infected erythrocytes and subsequent immune and inflammatory responses.
Herein, we review the genetic alterations associated with erythrocytes or mediators of the immune system, which might influence malaria outcome.
Moreover, polymorphisms in genes related to molecules involved in mechanisms of cytoadherence and their influence on malaria pathology are also discussed.
The results of some studies have suggested that the combinatorial effects of a set of genetic factors in the erythrocyte-immunology pathway might be relevant to host resistance or susceptibility against Plasmodium infection.
However, these results must be interpreted with caution because of the differences observed in the functionality and frequency of polymorphisms within different populations.
With the recent advances in molecular biology techniques, more robust studies with reliable data have been reported, and the results of these studies have identified individual genetic factors for consideration in preventing severe disease and the individual response to treatment.
American Psychological Association (APA)
de Mendonça, Vitor R. R.& Goncalves, Marilda Souza& Barral-Netto, Manoel. 2012. The Host Genetic Diversity in Malaria Infection. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-509933
Modern Language Association (MLA)
de Mendonça, Vitor R. R.…[et al.]. The Host Genetic Diversity in Malaria Infection. Journal of Tropical Medicine No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-509933
American Medical Association (AMA)
de Mendonça, Vitor R. R.& Goncalves, Marilda Souza& Barral-Netto, Manoel. The Host Genetic Diversity in Malaria Infection. Journal of Tropical Medicine. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-509933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509933