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Foxp3+ Regulatory T Cells in Mouse Models of Type 1 Diabetes
Joint Authors
Watts, Deepika
Kretschmer, Karsten
Petzold, Cathleen
Schallenberg, Sonja
Sparwasser, Tim
Riewaldt, Julia
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Studies on human type 1 diabetes (T1D) are facilitated by the availability of animal models such as nonobese diabetic (NOD) mice that spontaneously develop autoimmune diabetes, as well as a variety of genetically engineered mouse models with reduced genetic and pathogenic complexity, as compared to the spontaneous NOD model.
In recent years, increasing evidence has implicated CD4+CD25+ regulatory T (Treg) cells expressing the transcription factor Foxp3 in both the breakdown of self-tolerance and the restoration of immune homeostasis in T1D.
In this paper, we provide an overview of currently available mouse models to study the role of Foxp3+ Treg cells in the control of destructive β cell autoimmunity, including a novel NOD model that allows specific and temporally controlled deletion of Foxp3+ Treg cells.
American Psychological Association (APA)
Petzold, Cathleen& Riewaldt, Julia& Watts, Deepika& Sparwasser, Tim& Schallenberg, Sonja& Kretschmer, Karsten. 2013. Foxp3+ Regulatory T Cells in Mouse Models of Type 1 Diabetes. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-509942
Modern Language Association (MLA)
Petzold, Cathleen…[et al.]. Foxp3+ Regulatory T Cells in Mouse Models of Type 1 Diabetes. Journal of Diabetes Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-509942
American Medical Association (AMA)
Petzold, Cathleen& Riewaldt, Julia& Watts, Deepika& Sparwasser, Tim& Schallenberg, Sonja& Kretschmer, Karsten. Foxp3+ Regulatory T Cells in Mouse Models of Type 1 Diabetes. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-509942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509942