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Studying the Complex Expression Dependences between Sets of Coexpressed Genes
Joint Authors
Cedano, Juan
Querol, Enrique
Flores, Jose
Huerta, Mario
Casanova, Oriol
Barchino, Roberto
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Organisms simplify the orchestration of gene expression by coregulating genes whose products function together in the cell.
The use of clustering methods to obtain sets of coexpressed genes from expression arrays is very common; nevertheless there are no appropriate tools to study the expression networks among these sets of coexpressed genes.
The aim of the developed tools is to allow studying the complex expression dependences that exist between sets of coexpressed genes.
For this purpose, we start detecting the nonlinear expression relationships between pairs of genes, plus the coexpressed genes.
Next, we form networks among sets of coexpressed genes that maintain nonlinear expression dependences between all of them.
The expression relationship between the sets of coexpressed genes is defined by the expression relationship between the skeletons of these sets, where this skeleton represents the coexpressed genes with a well-defined nonlinear expression relationship with the skeleton of the other sets.
As a result, we can study the nonlinear expression relationships between a target gene and other sets of coexpressed genes, or start the study from the skeleton of the sets, to study the complex relationships of activation and deactivation between the sets of coexpressed genes that carry out the different cellular processes present in the expression experiments.
American Psychological Association (APA)
Huerta, Mario& Casanova, Oriol& Barchino, Roberto& Flores, Jose& Querol, Enrique& Cedano, Juan. 2014. Studying the Complex Expression Dependences between Sets of Coexpressed Genes. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-509952
Modern Language Association (MLA)
Huerta, Mario…[et al.]. Studying the Complex Expression Dependences between Sets of Coexpressed Genes. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-509952
American Medical Association (AMA)
Huerta, Mario& Casanova, Oriol& Barchino, Roberto& Flores, Jose& Querol, Enrique& Cedano, Juan. Studying the Complex Expression Dependences between Sets of Coexpressed Genes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-509952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509952