Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications
Joint Authors
DeSimone, Joseph M.
Kuehl, Philip
Garcia, Andres
Maynor, Benjamin W.
Shen, Tammy
Mack, Peter
Napier, Mary
Tully, Janet
Fromen, Catherine
Pillai, Jonathan
Williams, Stuart
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Particle Replication in Non-Wetting Templates (PRINT®) is a platform particle drug delivery technology that coopts the precision and nanoscale spatial resolution inherently afforded by lithographic techniques derived from the microelectronics industry to produce precisely engineered particles.
We describe the utility of PRINT technology as a strategy for formulation and delivery of small molecule and biologic therapeutics, highlighting previous studies where particle size, shape, and chemistry have been used to enhance systemic particle distribution properties.
In addition, we introduce the application of PRINT technology towards respiratory drug delivery, a particular interest due to the pharmaceutical need for increased control over dry powder characteristics to improve drug delivery and therapeutic indices.
To this end, we have produced dry powder particles with micro- and nanoscale geometric features and composed of small molecule and protein therapeutics.
Aerosols generated from these particles show attractive properties for efficient pulmonary delivery and differential respiratory deposition characteristics based on particle geometry.
This work highlights the advantages of adopting proven microfabrication techniques in achieving unprecedented control over particle geometric design for drug delivery.
American Psychological Association (APA)
Garcia, Andres& Mack, Peter& Williams, Stuart& Fromen, Catherine& Shen, Tammy& Tully, Janet…[et al.]. 2012. Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-509989
Modern Language Association (MLA)
Garcia, Andres…[et al.]. Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications. Journal of Drug Delivery No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-509989
American Medical Association (AMA)
Garcia, Andres& Mack, Peter& Williams, Stuart& Fromen, Catherine& Shen, Tammy& Tully, Janet…[et al.]. Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-509989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509989