HER-2 Expression in Immunohistochemistry Has No Prognostic Significance in Gastric Cancer Patients
Joint Authors
Biecek, Przemyslaw
Matkowski, Rafal
Rudno-Rudzinska, Julia
Halon, Agnieszka
Kielan, Wojciech
Donizy, Piotr
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The role of HER-2 expression as a prognostic factor in gastric cancer (GC) is still controversial.
The aim of the study was to asses HER-2 status, its correlations with clinicopathological parameters, and prognostic impact in GC patients.
Tumor samples were collected from 78 patients who had undergone curative surgery.
In order to evaluate the intensity of immunohistochemical (IHC) reactions two scales were applied: the immunoreactive score according to Remmele modified by the authors and standardised Hercep test score modified for GC by Hofmann et al.
The HER-2 overexpression was detected by IHC in 23 (29.5%) tumors in Hercep test (score 2+/3+) and in 24 (30.7%) in IRS scale (IRS 4–12).
The overexpression of HER-2 was associated with poorly differentiated tumors, but this correlation was not significant (P=0.064).
No relationship was found between HER-2 expression and primary tumor size and degree of spread to regional lymph nodes.
Both univariate and multivariate analyses revealed that TNM stage and patient’s age were the crucial negative prognostic factors.
No correlation was observed between patient survival and expression of HER-2 estimated using both scales.
This research did not confirm HER-2 expression (evaluated with immunohistochemistry) value as a prognostic tool in GC.
American Psychological Association (APA)
Halon, Agnieszka& Donizy, Piotr& Biecek, Przemyslaw& Rudno-Rudzinska, Julia& Kielan, Wojciech& Matkowski, Rafal. 2012. HER-2 Expression in Immunohistochemistry Has No Prognostic Significance in Gastric Cancer Patients. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-509992
Modern Language Association (MLA)
Halon, Agnieszka…[et al.]. HER-2 Expression in Immunohistochemistry Has No Prognostic Significance in Gastric Cancer Patients. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-509992
American Medical Association (AMA)
Halon, Agnieszka& Donizy, Piotr& Biecek, Przemyslaw& Rudno-Rudzinska, Julia& Kielan, Wojciech& Matkowski, Rafal. HER-2 Expression in Immunohistochemistry Has No Prognostic Significance in Gastric Cancer Patients. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-509992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509992