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Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation
Joint Authors
Chanvorachote, Pithi
Chunhacha, Preedakorn
Pongrakhananon, Varisa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nitric oxide (NO) in tumor microenvironment may have a significant impact on metastatic behaviors of cancer.
Noncytotoxic doses of NO enhanced anoikis resistance and migration in lung cancer H23 cells via an increase in lamellipodia, epithelial-mesenchymal transition (EMT) markers including vimentin and snail, and caveolin-1 (Cav-1).
However, the induction of EMT was found in Cav-1-knock down cells treated with NO, suggesting that EMT was through Cav-1-independent pathway.
These effects of NO were consistently observed in other lung cancer cells including H292 and H460 cells.
These findings highlight the novel role of NO on EMT and metastatic behaviors of cancer cells.
American Psychological Association (APA)
Chanvorachote, Pithi& Pongrakhananon, Varisa& Chunhacha, Preedakorn. 2014. Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-510001
Modern Language Association (MLA)
Chanvorachote, Pithi…[et al.]. Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-510001
American Medical Association (AMA)
Chanvorachote, Pithi& Pongrakhananon, Varisa& Chunhacha, Preedakorn. Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-510001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510001