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Sorafenib-Induced Liver Failure : A Case Report and Review of the Literature
Joint Authors
Van Steenbergen, Werner
Verslype, Chris
Van Hootegem, Anneleen
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
In patients with hepatocellular carcinoma characterized by vascular invasion and/or extrahepatic disease, Sorafenib is considered treatment of choice.
Although mild liver test abnormalities were reported in less than 1% of the patients in the two large randomized, controlled phase III trials, four cases of severe acute Sorafenib-induced hepatitis have been described.
One of these four cases died from liver failure.
In this paper, a patient with HCC with lung metastases developed high fever and a severe hepatitis that rapidly evolved into liver coma and death, two weeks after the initiation of Sorafenib.
Biochemical parameters pointed to a hepatocellular type of injury.
Clinical and biochemical presentations were compatible with a drug-induced hypersensitivity syndrome such as it has mainly been described for aromatic anticonvulsants, sulphonamides, and allopurinol.
We hypothesize that an underlying cytochrome P450 dysfunction with the presence of reactive drug metabolites might lead to this potentially fatal Sorafenib-induced severe liver dysfunction.
American Psychological Association (APA)
Van Hootegem, Anneleen& Verslype, Chris& Van Steenbergen, Werner. 2011. Sorafenib-Induced Liver Failure : A Case Report and Review of the Literature. Case Reports in Hepatology،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-510005
Modern Language Association (MLA)
Van Hootegem, Anneleen…[et al.]. Sorafenib-Induced Liver Failure : A Case Report and Review of the Literature. Case Reports in Hepatology No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-510005
American Medical Association (AMA)
Van Hootegem, Anneleen& Verslype, Chris& Van Steenbergen, Werner. Sorafenib-Induced Liver Failure : A Case Report and Review of the Literature. Case Reports in Hepatology. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-510005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510005