Dendritic Cells in Human Atherosclerosis : From Circulation to Atherosclerotic Plaques
Joint Authors
Vrints, Christiaan J.
Van Brussel, Ilse
Bult, Hidde
Bosmans, Johan M.
Van Vré, Emily A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Atherosclerosis is a chronic inflammatory disease with atherosclerotic plaques containing inflammatory infiltrates predominantly consisting of monocytes/macrophages and activated T cells.
More recent is the implication of dendritic cells (DCs) in the disease.
Since DCs were demonstrated in human arteries in 1995, numerous studies in humans suggest a role for these professional antigen-presenting cells in atherosclerosis.
Aim.
This paper focuses on the observations made in blood and arteries of patients with atherosclerosis.
In principal, flow cytometric analyses show that circulating myeloid (m) and plasmacytoid (p) DCs are diminished in coronary artery disease, while immunohistochemical studies describe increased intimal DC counts with evolving plaque stages.
Moreover, mDCs and pDCs appear to behave differently in atherosclerosis.
Yet, the origin of plaque DCs and their relationship with blood DCs are unknown.
Therefore, several explanations for the observed changes are postulated.
In addition, the technical challenges and discrepancies in the research field are discussed.
Future.
Future studies in humans, in combination with experimental animal studies will unravel mechanisms leading to altered blood and plaque DCs in atherosclerosis.
As DCs are crucial for inducing but also dampening immune responses, understanding their life cycle, trafficking and function in atherosclerosis will determine potential use of DCs in antiatherogenic therapies.
American Psychological Association (APA)
Van Vré, Emily A.& Van Brussel, Ilse& Bosmans, Johan M.& Vrints, Christiaan J.& Bult, Hidde. 2011. Dendritic Cells in Human Atherosclerosis : From Circulation to Atherosclerotic Plaques. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-510006
Modern Language Association (MLA)
Van Vré, Emily A.…[et al.]. Dendritic Cells in Human Atherosclerosis : From Circulation to Atherosclerotic Plaques. Mediators of Inflammation No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-510006
American Medical Association (AMA)
Van Vré, Emily A.& Van Brussel, Ilse& Bosmans, Johan M.& Vrints, Christiaan J.& Bult, Hidde. Dendritic Cells in Human Atherosclerosis : From Circulation to Atherosclerotic Plaques. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-510006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510006