Mediators of Pruritus in Lichen Planus
Joint Authors
Welz-Kubiak, Kalina
Reich, Adam
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-21
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Lichen planus (LP) is an inflammatory mucocutaneous disease, showing a wide variety of clinical subtypes.
The classic presentation of LP involves the appearance of polygonal, flat-topped, violaceous papules and plaques with reticulated white lines, termed “Wickham's striae”.
Cutaneous lesions tend to be extremely pruritic, and this symptom does not subside after common antipruritic treatment.
Moreover, based on our previous pilot study, it could be stated, that itch is the most unpleasant and bothersome symptom of LP for majority of patients suffering from this disease.
However, the underlying mechanisms of itch in lichen planus remain still unknown.
In addition, there is no study on mediators of this sensation, but taking into account pathogenesis of LP there are some possible mediators implicated to transmit or modulate itch.
In pathogenesis of LP important are such mechanisms as apoptosis, autoimmune reaction, and role of stress.
With these pathways some, previously described in other diseases, itch mediators such as cytokines, proteases, and opioid system are connected.
Whether these mechanisms are involved in pruritus accompanying LP requires further investigation.
Limited knowledge of pruritus origin in lichen planus is responsible for the lack of the effective antipruritic treatments.
Here, we describe possible mechanisms participating the pathogenesis of pruritus in lichen planus.
American Psychological Association (APA)
Welz-Kubiak, Kalina& Reich, Adam. 2013. Mediators of Pruritus in Lichen Planus. Autoimmune Diseases،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-510010
Modern Language Association (MLA)
Welz-Kubiak, Kalina& Reich, Adam. Mediators of Pruritus in Lichen Planus. Autoimmune Diseases No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-510010
American Medical Association (AMA)
Welz-Kubiak, Kalina& Reich, Adam. Mediators of Pruritus in Lichen Planus. Autoimmune Diseases. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-510010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510010