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Prevalence of Past and Reactivated Viral Infections and Efficacy of Cyclosporine A as Monotherapy or in Combination in Patients with Psoriatic Arthritis—Synergy Study : A Longitudinal Observational Study
Joint Authors
Colombo, Delia
Marchesoni, Antonio
Parodi, Aurora
Gargiulo, Anna
Simoni, Lucia
Grossi, Paolo
Di Nuzzo, Sergio
Chimenti, Sergio
Bellia, Gilberto
Griseta, Vito
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We have prospectively evaluated psoriatic arthritis (PsA) patients for (1) seropositivity for former viral infections and seroconversion and (2) efficacy of cyclosporine A (CsA) alone or in combination with other immunosuppressants in a time period of 12 months.
Screening included HBV antibodies and antigens, HCV antibodies and RNA, HSV 1-2, HZV, EBV, and CMV IgG, and IgM, HHV-6 DNA, and HIV 1-2 antibodies.
PsA was evaluated by the Psoriasis Area Severity Index (PASI), the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and the Visual Analogue Scale (VAS).
At baseline, 126 (56%) out of 225 evaluable patients had 2 or more seropositivities indicative of former infections, and 31 patients (13.8%) presented seropositivity for HCV, HBV, HSV-1 and -2, HHV-6, EBV, or parvovirus infection; one of them, positive for HBAg, was treated with lamivudine, while the remaining 30 received no specific treatment.
None of the 31 patients developed virus reactivation.
A reduction (P<0.001) of PASI, BASDAI, and VAS scores was observed at 6 and 12 months.
The treatment of PsA with CsA as monotherapy or in combination was safe and effective.
In vitro experiments and clinical findings, including those from our study, suggest that CsA as monotherapy or in combination with biologics might be the treatment of choice in PsA HCV-positive patients.
American Psychological Association (APA)
Colombo, Delia& Chimenti, Sergio& Grossi, Paolo& Marchesoni, Antonio& Di Nuzzo, Sergio& Griseta, Vito…[et al.]. 2014. Prevalence of Past and Reactivated Viral Infections and Efficacy of Cyclosporine A as Monotherapy or in Combination in Patients with Psoriatic Arthritis—Synergy Study : A Longitudinal Observational Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-510046
Modern Language Association (MLA)
Colombo, Delia…[et al.]. Prevalence of Past and Reactivated Viral Infections and Efficacy of Cyclosporine A as Monotherapy or in Combination in Patients with Psoriatic Arthritis—Synergy Study : A Longitudinal Observational Study. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-510046
American Medical Association (AMA)
Colombo, Delia& Chimenti, Sergio& Grossi, Paolo& Marchesoni, Antonio& Di Nuzzo, Sergio& Griseta, Vito…[et al.]. Prevalence of Past and Reactivated Viral Infections and Efficacy of Cyclosporine A as Monotherapy or in Combination in Patients with Psoriatic Arthritis—Synergy Study : A Longitudinal Observational Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-510046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510046