Targeting the Mechanisms of Resistance to Chemotherapy and Radiotherapy with the Cancer Stem Cell Hypothesis
Joint Authors
Morrison, Ryan
Chung, Christine H.
Lu, Bo
Spratt, Daniel E.
Niermann, Kenneth J.
Schleicher, Stephen M.
Kim, Sungjune
Sun, Yunguang
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Despite advances in treatment, cancer remains the 2nd most common cause of death in the United States.
Poor cure rates may result from the ability of cancer to recur and spread after initial therapies have seemingly eliminated detectable signs of disease.
A growing body of evidence supports a role for cancer stem cells (CSCs) in tumor regrowth and spread after initial treatment.
Thus, targeting CSCs in combination with traditional induction therapies may improve treatment outcomes and survival rates.
Unfortunately, CSCs tend to be resistant to chemo- and radiation therapy, and a better understanding of the mechanisms underlying CSC resistance to treatment is necessary.
This paper provides an update on evidence that supports a fundamental role for CSCs in cancer progression, summarizes potential mechanisms of CSC resistance to treatment, and discusses classes of drugs currently in preclinical or clinical testing that show promise at targeting CSCs.
American Psychological Association (APA)
Morrison, Ryan& Schleicher, Stephen M.& Sun, Yunguang& Niermann, Kenneth J.& Kim, Sungjune& Spratt, Daniel E.…[et al.]. 2010. Targeting the Mechanisms of Resistance to Chemotherapy and Radiotherapy with the Cancer Stem Cell Hypothesis. Journal of Oncology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-510057
Modern Language Association (MLA)
Morrison, Ryan…[et al.]. Targeting the Mechanisms of Resistance to Chemotherapy and Radiotherapy with the Cancer Stem Cell Hypothesis. Journal of Oncology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-510057
American Medical Association (AMA)
Morrison, Ryan& Schleicher, Stephen M.& Sun, Yunguang& Niermann, Kenneth J.& Kim, Sungjune& Spratt, Daniel E.…[et al.]. Targeting the Mechanisms of Resistance to Chemotherapy and Radiotherapy with the Cancer Stem Cell Hypothesis. Journal of Oncology. 2010. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-510057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510057