Increased NTPDase Activity in Lymphocytes during Experimental Sepsis
Joint Authors
Pinheiro, Kelly de Vargas
Schetinger, Maria Rosa Chitolina
Leal, Cláudio Alberto Martins
Luz, Sônia Cristina Almeida
Jaques, Jeandre Augusto dos Santos
Leal, Daniela Bitencourt Rosa
Bertoncheli, Claudia de Mello
Stainki, Daniel Roulim
Zimmermann, Carine Eloise Prestes
Souza, Viviane do Carmo Gonçalves
Ruchel, Jader Betsch
Rocha, Bruna Cipolatto
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
We investigated in rats induced to sepsis the activity of ectonucleoside triphosphate diphosphohydrolase (NTPDase; CD39; E.C.
3.6.1.5), an enzyme involved in the modulation of immune responses.
After 12 hours of surgery, lymphocytes were isolated from blood and NTPDase activity was determined.
It was also performed the histology of kidney, liver, and lung.
The results demonstrated an increase in the hydrolysis of adenosine-5′-triphosphate (ATP) (P<0.01), but no changes regarding adenosine-5′-monophosphate (ADP) hydrolysis (P>0.05).
Histological analysis showed several morphological changes in the septic group, such as vascular congestion, necrosis, and infiltration of mononuclear cells.
It is known that the intracellular milieu contains much more ATP nucleotides than the extracellular.
In this context, the increased ATPasic activity was probably induced as a dynamic response to clean up the elevated ATP levels resulting from cellular death.
American Psychological Association (APA)
Bertoncheli, Claudia de Mello& Zimmermann, Carine Eloise Prestes& Jaques, Jeandre Augusto dos Santos& Leal, Cláudio Alberto Martins& Ruchel, Jader Betsch& Rocha, Bruna Cipolatto…[et al.]. 2012. Increased NTPDase Activity in Lymphocytes during Experimental Sepsis. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-510061
Modern Language Association (MLA)
Bertoncheli, Claudia de Mello…[et al.]. Increased NTPDase Activity in Lymphocytes during Experimental Sepsis. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-510061
American Medical Association (AMA)
Bertoncheli, Claudia de Mello& Zimmermann, Carine Eloise Prestes& Jaques, Jeandre Augusto dos Santos& Leal, Cláudio Alberto Martins& Ruchel, Jader Betsch& Rocha, Bruna Cipolatto…[et al.]. Increased NTPDase Activity in Lymphocytes during Experimental Sepsis. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-510061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510061