Revisiting the Marrow Metabolic Changes after Chemotherapy in Lymphoma : A Step towards Personalized Care
Joint Authors
Wong, Christiana O.
Tang, Bingfeng
Wu, Dafang
Wood, Daniel
Patel, Malaykumar M.
Khong, Pek Lan
Oliver Wong, Ching-Yee
Wong, Regina H.
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
The aims were to correlate individual marrow metabolic changes after chemotherapy with bone marrow biopsy (BMBx) for its potential value of personalized care in lymphoma.
Methods.
26 patients (mean age, 58 ± 15 y; 13 female, 13 male) with follicular lymphoma or diffuse large B-cell lymphoma, referred to FDG-PET/CT imaging, who had BMBx from unilateral or bilateral iliac crest(s) before chemotherapy, were studied retrospectively.
The maximal standardized uptake value (SUV) was measured from BMBx site over the same area on both initial staging and first available restaging FDG-PET/CT scan.
Results.
35 BMBx sites in 26 patients were evaluated.
12 of 35 sites were BMBx positive with interval decrease in SUV in 11 of 12 sites (92%).
The remaining 23 of 35 sites were BMBx negative with interval increase in SUV in 21 of 23 sites (91%).
The correlation between SUV change over the BMBx site before and after chemotherapy and BMBx result was significant (P<0.0001).
Conclusions.
This preliminary result demonstrates a strong correlation between marrow metabolic changes (as determined by FDG PET) after chemotherapy and bone marrow involvement proven by biopsy.
This may provide a retrospective means of personalized management of marrow involvement in deciding whether to deliver more extended therapy or closer followup of lymphoma patients.
American Psychological Association (APA)
Tang, Bingfeng& Patel, Malaykumar M.& Wong, Regina H.& Wood, Daniel& Wong, Christiana O.& Wu, Dafang…[et al.]. 2011. Revisiting the Marrow Metabolic Changes after Chemotherapy in Lymphoma : A Step towards Personalized Care. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-510078
Modern Language Association (MLA)
Tang, Bingfeng…[et al.]. Revisiting the Marrow Metabolic Changes after Chemotherapy in Lymphoma : A Step towards Personalized Care. International Journal of Molecular Imaging No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-510078
American Medical Association (AMA)
Tang, Bingfeng& Patel, Malaykumar M.& Wong, Regina H.& Wood, Daniel& Wong, Christiana O.& Wu, Dafang…[et al.]. Revisiting the Marrow Metabolic Changes after Chemotherapy in Lymphoma : A Step towards Personalized Care. International Journal of Molecular Imaging. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-510078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510078