Influence of leptin in the development of osteoporosis; clinical, serological and radiological study

Abstract EN

Subjects : the study was performed on 2 groups; group I included 20 pre-menopausal women while group II included 20 post-menopausal women, the duration since menopause ranged from 2-18 years.

Method : Anthropometric measurements were done for both groups including BMI, body fat %, measurement the circumference of hip, waist 1, waist 2, thigh and WHR1, WHR2, WTR1, WTR2 were calculated.

Measurement of serum leptin, -crosslaps and hormonal sex profile were done for both groups.

Measurement of BMD with dexa was done for group II only.

Results : No significant difference was found in BMI and serum lepton level in both groups of the study, while highly significant difference was observed in body fat %, fat distribution sites and hormonal sex profile.

There was a significant correlation between serum lepton and both BMI and total body fat also with some parameters of body fat distribution.

Also, a highly significant correlation was noticed between plasma lepton level and BMD.

We did not find any significant correlation between E2 or FSH level and plasma leptin level in both groups of the study.

As for-cross laps, we found a high significant correlation between it and leptin and also between it and BMD.

We even found 2 cases with elevated CTX and normal BMD.

Conclusion: Circulating plasma leptin may have a significant direct influence on bone mass in postmenopausal women.

So it may be useful in the future for further research to use its antagonist in the treatment of osteoporosis.

Again, serum cross laps measurements may be used for selecting individuals with high bone resumption who are at an increased risk of developing osteoporosis.