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Ex Vivo Fluorescence Molecular Tomography of the Spine
Joint Authors
Pimpalkhare, Monish
Venugopal, Vivek
Chen, Jin
Intes, Xavier
Source
International Journal of Biomedical Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We investigated the potential of fluorescence molecular tomography to image ex vivo samples collected from a large animal model, in this case, a dog spine.
Wide-field time-gated fluorescence tomography was employed to assess the impact of multiview acquisition, data type, and intrinsic optical properties on the localization and quantification accuracy in imaging a fluorescent inclusion in the intervertebral disk.
As expected, the TG data sets, when combining early and late gates, provide significantly better performances than the CW data sets in terms of localization and quantification.
Moreover, the use of multiview imaging protocols led to more accurate localization.
Additionally, the incorporation of the heterogeneous nature of the tissue in the model to compute the Jacobians led to improved imaging performances.
This preliminary imaging study provides a proof of concept of the feasibility of quantitatively imaging complex ex vivo samples nondestructively and with short acquisition times.
This work is the first step towards employing optical molecular imaging of the spine to detect and characterize disc degeneration based on targeted fluorescent probes.
American Psychological Association (APA)
Pimpalkhare, Monish& Chen, Jin& Venugopal, Vivek& Intes, Xavier. 2012. Ex Vivo Fluorescence Molecular Tomography of the Spine. International Journal of Biomedical Imaging،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-510103
Modern Language Association (MLA)
Pimpalkhare, Monish…[et al.]. Ex Vivo Fluorescence Molecular Tomography of the Spine. International Journal of Biomedical Imaging No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-510103
American Medical Association (AMA)
Pimpalkhare, Monish& Chen, Jin& Venugopal, Vivek& Intes, Xavier. Ex Vivo Fluorescence Molecular Tomography of the Spine. International Journal of Biomedical Imaging. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-510103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510103