Models for LRRK2-Linked Parkinsonism
Joint Authors
Yang, DeJun
Li, Tianxia
Liu, Zhaohui
Sushchky, Sarah
Smith, Wanli W.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-07
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder characterized by the selective loss of dopaminergic neurons and the presence of Lewy bodies.
The pathogenesis of PD is not fully understood, but it appears to involve both genetic susceptibility and environmental factors.
Treatment for PD that prevents neuronal death progression in the dopaminergic system and abnormal protein deposition in the brain is not yet available.
Recently, mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified to cause autosomal-dominant late-onset PD and contribute to sporadic PD.
Here, we review the recent models for LRRK2-linked Parkinsonism and their utility in studying LRRK2 neurobiology, pathogenesis, and potential therapeutics.
American Psychological Association (APA)
Li, Tianxia& Yang, DeJun& Sushchky, Sarah& Liu, Zhaohui& Smith, Wanli W.. 2011. Models for LRRK2-Linked Parkinsonism. ISRN Physical Chemistry،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-510115
Modern Language Association (MLA)
Li, Tianxia…[et al.]. Models for LRRK2-Linked Parkinsonism. ISRN Physical Chemistry No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-510115
American Medical Association (AMA)
Li, Tianxia& Yang, DeJun& Sushchky, Sarah& Liu, Zhaohui& Smith, Wanli W.. Models for LRRK2-Linked Parkinsonism. ISRN Physical Chemistry. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-510115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510115