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The Oxidative State of Chylomicron Remnants Influences Their Modulation of Human Monocyte Activation
Joint Authors
Lawson, Charlotte
Armengol Lopez, Sandra
Botham, Kathleen M.
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chylomicron remnants (CMRs) contribute directly to human monocyte activation in vitro, by increasing reactive oxygen species (ROS) production and cell migration.
In this study, the effects of the oxidative state of CMR on the degree of monocyte activation was investigated.
CMR-like particles (CRLPs) were prepared in three different oxidative states, normal (CRLPs), protected from oxidation by incorporation of the antioxidant, probucol (pCRLPs), or oxidised with CuSO4 (oxCRLPs).
Lipid accumulation and ROS production were significantly increased in primary human monocytes incubated with CRLPs, whilst secretion on monocyte chemoattractant protein-1 was reduced, but oxCRLPs had no additional effect.
In contrast, pCRLPs were taken up by monocytes to a lesser extent and had no significant effect on ROS or MCP-1 secretion.
These studies suggest that the oxidative state of CMRs modulates their stimulation of the activation of peripheral blood human monocytes and that dietary antioxidants may provide some protection against these atherogenic effects.
American Psychological Association (APA)
Armengol Lopez, Sandra& Botham, Kathleen M.& Lawson, Charlotte. 2011. The Oxidative State of Chylomicron Remnants Influences Their Modulation of Human Monocyte Activation. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-510123
Modern Language Association (MLA)
Armengol Lopez, Sandra…[et al.]. The Oxidative State of Chylomicron Remnants Influences Their Modulation of Human Monocyte Activation. International Journal of Vascular Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-510123
American Medical Association (AMA)
Armengol Lopez, Sandra& Botham, Kathleen M.& Lawson, Charlotte. The Oxidative State of Chylomicron Remnants Influences Their Modulation of Human Monocyte Activation. International Journal of Vascular Medicine. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-510123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510123