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Helminth Parasites and the Modulation of Joint Inflammation
Joint Authors
Matisz, Chelsea E.
McKay, Derek M.
Sharkey, Keith A.
McDougall, Jason J.
Source
Journal of Parasitology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
There is an urgent need to develop better therapeutics for autoimmune and autoinflammatory diseases, of which musculoskeletal disorders such as rheumatoid arthritis are particularly prevalent and debilitating.
Helminth parasites are accomplished masters at modifying their hosts' immune activity, and so attention has focused on rodent-helminth model systems to uncover the workings of the mammalian immune response to metazoan parasites, with the hope of revealing molecules and/or mechanisms that can be translated into better treatments for human autoimmune and idiopathic disorders.
Substantial proof-of-principal data supporting the concept that infection with helminth parasites can reduce the severity of concomitant disease has been amassed from models of mucosal inflammation.
Indeed, infection with helminth parasites has been tried as a therapy in inflammatory bowel disease, and there are case reports relating to other conditions (e.g., autism); however, the impact of infection with parasitic helminths on musculoskeletal diseases has not been extensively studied.
Here, we present the view that such a strategy should be applied to the amelioration of joint inflammation and review the literature that supports this contention.
American Psychological Association (APA)
Matisz, Chelsea E.& McDougall, Jason J.& Sharkey, Keith A.& McKay, Derek M.. 2011. Helminth Parasites and the Modulation of Joint Inflammation. Journal of Parasitology Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-510131
Modern Language Association (MLA)
Matisz, Chelsea E.…[et al.]. Helminth Parasites and the Modulation of Joint Inflammation. Journal of Parasitology Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-510131
American Medical Association (AMA)
Matisz, Chelsea E.& McDougall, Jason J.& Sharkey, Keith A.& McKay, Derek M.. Helminth Parasites and the Modulation of Joint Inflammation. Journal of Parasitology Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-510131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510131