New SPECT and PET Radiopharmaceuticals for Imaging Cardiovascular Disease
Joint Authors
Pelletier-Galarneau, Matthieu
Ruddy, Terrence D.
Wells, R. Glenn
Schindler, Thomas H.
Sogbein, Oyebola O.
Wei, Lihui
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Nuclear cardiology has experienced exponential growth within the past four decades with converging capacity to diagnose and influence management of a variety of cardiovascular diseases.
Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with technetium-99m radiotracers or thallium-201 has dominated the field; however new hardware and software designs that optimize image quality with reduced radiation exposure are fuelling a resurgence of interest at the preclinical and clinical levels to expand beyond MPI.
Other imaging modalities including positron emission tomography (PET) and magnetic resonance imaging (MRI) continue to emerge as powerful players with an expanded capacity to diagnose a variety of cardiac conditions.
At the forefront of this resurgence is the development of novel target vectors based on an enhanced understanding of the underlying pathophysiological process in the subcellular domain.
Molecular imaging with novel radiopharmaceuticals engineered to target a specific subcellular process has the capacity to improve diagnostic accuracy and deliver enhanced prognostic information to alter management.
This paper, while not comprehensive, will review the recent advancements in radiotracer development for SPECT and PET MPI, autonomic dysfunction, apoptosis, atherosclerotic plaques, metabolism, and viability.
The relevant radiochemistry and preclinical and clinical development in addition to molecular imaging with emerging modalities such as cardiac MRI and PET-MR will be discussed.
American Psychological Association (APA)
Sogbein, Oyebola O.& Pelletier-Galarneau, Matthieu& Schindler, Thomas H.& Wei, Lihui& Wells, R. Glenn& Ruddy, Terrence D.. 2014. New SPECT and PET Radiopharmaceuticals for Imaging Cardiovascular Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-510160
Modern Language Association (MLA)
Sogbein, Oyebola O.…[et al.]. New SPECT and PET Radiopharmaceuticals for Imaging Cardiovascular Disease. BioMed Research International No. 2014 (2014), pp.1-24.
https://search.emarefa.net/detail/BIM-510160
American Medical Association (AMA)
Sogbein, Oyebola O.& Pelletier-Galarneau, Matthieu& Schindler, Thomas H.& Wei, Lihui& Wells, R. Glenn& Ruddy, Terrence D.. New SPECT and PET Radiopharmaceuticals for Imaging Cardiovascular Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-510160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510160