![](/images/graphics-bg.png)
Geometric Analysis of Alloreactive HLA α-Helices
Joint Authors
Schreiner, Wolfgang
Ribarics, Reiner
Ilieva, Nevena
Karch, Rudolf
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Molecular dynamics (MD) is a valuable tool for the investigation of functional elements in biomolecules, providing information on dynamic properties and processes.
Previous work by our group has characterized static geometric properties of the two MHC α-helices comprising the peptide binding region recognized by T cells.
We build upon this work and used several spline models to approximate the overall shape of MHC α-helices.
We applied this technique to a series of MD simulations of alloreactive MHC molecules that allowed us to capture the dynamics of MHC α-helices’ steric configurations.
Here, we discuss the variability of spline models underlying the geometric analysis with varying polynomial degrees of the splines.
American Psychological Association (APA)
Ribarics, Reiner& Karch, Rudolf& Ilieva, Nevena& Schreiner, Wolfgang. 2014. Geometric Analysis of Alloreactive HLA α-Helices. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-510185
Modern Language Association (MLA)
Ribarics, Reiner…[et al.]. Geometric Analysis of Alloreactive HLA α-Helices. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-510185
American Medical Association (AMA)
Ribarics, Reiner& Karch, Rudolf& Ilieva, Nevena& Schreiner, Wolfgang. Geometric Analysis of Alloreactive HLA α-Helices. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-510185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510185