Insights into the Function of the Unstructured N-Terminal Domain of Proteins 4.1R and 4.1G in Erythropoiesis
Joint Authors
Gascard, Philippe
Takakuwa, Yuichi
Nunomura, Wataru
Source
International Journal of Cell Biology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Membrane skeletal protein 4.1R is the prototypical member of a family of four highly paralogous proteins that include 4.1G, 4.1N, and 4.1B.
Two isoforms of 4.1R (4.1R135 and 4.1R80), as well as 4.1G, are expressed in erythroblasts during terminal differentiation, but only 4.1R80 is present in mature erythrocytes.
One goal in the field is to better understand the complex regulation of cell type and isoform-specific expression of 4.1 proteins.
To start answering these questions, we are studying in depth the important functions of 4.1 proteins in the organization and function of the membrane skeleton in erythrocytes.
We have previously reported that the binding profiles of 4.1R80 and 4.1R135 to membrane proteins and calmodulin are very different despite the similar structure of the membrane-binding domain of 4.1G and 4.1R135.
We have accumulated evidence for those differences being caused by the N-terminal 209 amino acids headpiece region (HP).
Interestingly, the HP region is an unstructured domain.
Here we present an overview of the differences and similarities between 4.1 isoforms and paralogs.
We also discuss the biological significance of unstructured domains.
American Psychological Association (APA)
Nunomura, Wataru& Gascard, Philippe& Takakuwa, Yuichi. 2011. Insights into the Function of the Unstructured N-Terminal Domain of Proteins 4.1R and 4.1G in Erythropoiesis. International Journal of Cell Biology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-510193
Modern Language Association (MLA)
Nunomura, Wataru…[et al.]. Insights into the Function of the Unstructured N-Terminal Domain of Proteins 4.1R and 4.1G in Erythropoiesis. International Journal of Cell Biology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-510193
American Medical Association (AMA)
Nunomura, Wataru& Gascard, Philippe& Takakuwa, Yuichi. Insights into the Function of the Unstructured N-Terminal Domain of Proteins 4.1R and 4.1G in Erythropoiesis. International Journal of Cell Biology. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-510193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510193